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The effect of intraocular 6‐hydroxydopamine on retinal processing of primates
Author(s) -
Ghilardi Maria Felice,
Marx Marcia S.,
BodisWollner Ivan,
Camras Carl B.,
Glover Andrew A.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250407
Subject(s) - hydroxydopamine , retinal , catecholaminergic , mptp , electroretinography , neuroscience , ophthalmology , evoked potential , retina , medicine , biology , dopamine , dopaminergic
In previous studies, we showed that in the monkey, systemically administered N‐methyl, 4‐phenyl, 1‐2‐3‐6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency‐dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We describe the effect of intravitreally administered 6‐hydroxydopamine (6‐OH‐DA) on the pattern electroretinogram and pattern visual evoked potential of 3 aphakic monkeys. Because of the aphake condition, several complexities of intravitreal injection of 6‐OH‐DA could be avoided. Nevertheless, following 6‐OH‐DA treatment, both the phase and the amplitude of pattern electroretinogram and pattern visual evoked potential became abnormal. This abnormality was most pronounced for the higher spatial frequencies (2.5 and 3.5 cycles per degree), whereas lower spatial frequencies (0.5 and 1.2 cycles per degree) were less impaired. The effects of systemically administered MPTP on pattern electroretinogram and pattern visual evoked potential are similar to the effects of intravitreal injections of 6‐OH‐DA, suggesting that a retinal catecholaminergic system plays an important role in pattern vision of primates.