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Controlled release of dopamine from a polymeric brain implant: In vivo characterization
Author(s) -
During Matthew J.,
Freese Andrew,
Sabel Bernhard A.,
Saltzman W. Mark,
Deutch Ariel,
Roth Robert H.,
Langer Robert
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250406
Subject(s) - microdialysis , dopamine , implant , in vivo , striatum , brain implant , neurotransmitter , chemistry , medicine , biomedical engineering , surgery , biology , central nervous system , microbiology and biotechnology
Abstract Intracerebral microdialysis was used to evaluate the long‐term in vivo release of dopamine from ethylene‐vinyl acetate (EV Ac)‐dopamine copolymer matrix discs for up to 65 days following striatal implantation. Dopamine release occurred through a single cavity present on one side of the disc, which was otherwise fully coated with an additional, impermeable layer of EV Ac. At 20 days following implantation of the device, extracellular concentrations of dopamine within the striatum reached micromolar levels, over 200‐fold greater than control values. Release of dopamine was shown to be stable and maintained for the 2‐month duration of the experiment. Histological examination confirmed the biocompatible nature of the implant. There are potential applications of this technology to the treatment of Parkinson's disease and other neurological and psychiatric disorders.