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The time course of steroid action on blood‐to‐brain and blood‐to‐tumor transport of 82 Rb: A positron emission tomographic study
Author(s) -
Jarden J. O.,
Dhawan V.,
Moeller J. R.,
Strother S. C.,
Rottenberg D. A.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250306
Subject(s) - positron emission tomography , positron , nuclear medicine , action (physics) , medicine , positron emission , physics , nuclear physics , quantum mechanics , electron
Blood‐to‐brain and blood‐to‐tumor transport rate constants for Rb (K 1 ) and apparent tissue blood volume (V b ) were estimated in 8 patients with primary or metastatic brain tumors before and approximately 6 hours after a 100‐mg intravenous bolus injection of dexamethasone using 82 Rb and positron emission tomography. Eight additional patients were studied to evaluate test‐retest variability and repositioning errors. Six hours following dexamethasone administration tumor K 1 (but not V b ) was significantly reduced compared with contralateral control brain regions ( p < 0.03). These data are consistent with our previously published 24‐hour‐postdexamethasone data and suggest that comparable effects of corticosteroids on brain/tumor capillaries may be observed at 5 to 6 and 24 hours. The time course of dexamethasone‐induced alterations in brain/tumor capillary permeability supports the view that these alterations may be responsible for at least some of the antiedema effects of corticosteroids.