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Transient neonatal hyperglycinemia
Author(s) -
Schiffmann Raphael,
Kaye Edward M.,
Willis John K.,
Africk Diane,
Ampola Mary
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250218
Subject(s) - hyperglycinemia , cerebrospinal fluid , medicine , glycine , pediatrics , chemistry , biochemistry , amino acid
Two patients with neonatal seizures and subsequent normal neurological development were found to have nonketotic hyperglycinemia. In both patients, hyperglycinemia resolved at 6 weeks of age. After cerebrospinal fluid glycine levels were normalized, the seizures stopped completely in one child and were markedly improved in the other. The possible mechanisms for the hyperglycinemia are discussed.