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Effect of digitalis on central demyelinative conduction block in vivo
Author(s) -
Kaji Ryuji,
Sumner Austin J.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250209
Subject(s) - digitalis , ouabain , hyperpolarization (physics) , membrane potential , chemistry , neuroscience , depolarization , medicine , pharmacology , sodium , biology , heart failure , organic chemistry , nuclear magnetic resonance spectroscopy
In searching for agents effective in treating multiple sclerosis, we studied the effect of a short‐acting digitalis, ouabain, on conduction block in an animal model of central nervous system demyelination. The electrogenic sodium/potassium pump, which digitalis specifically inhibits, is responsible for part of the resting membrane potential and also the activity‐related membrane hyperpolarization following high‐frequency impulses. The latter causes intermittent conduction block in demyelinated fibers. Therefore, digitalis might be expected to reverse demyelinative conduction blocks by reducing the threshold at the blocking node. Somatosensory evoked potentials were monitored in 11 rats with spinal cord demyelination before and after systemic administration of ouabain (0.1–0.6 mg or 0.21–1.58 mg/kg IP). In all rats, slowed conduction velocity of the compound action potential through the lesion was significantly reversed, and failure to transmit high‐frequency impulses was improved upon. The amplitude of the cortical somatosensory evoked potentials also increased significantly. Digitalis is a promising therapeutic agent for trial in patients with multiple sclerosis.