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Acetylcholinesterase‐rich pyramidal neurons in the human neocortex and hippocampus: Absence at birth, development during the life span, and dissolution in Alzheimer's disease
Author(s) -
Mesulam M.Marchsel,
Geula Changiz
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240611
Subject(s) - neocortex , neuroscience , hippocampus , hippocampal formation , acetylcholinesterase , pyramidal cell , alzheimer's disease , biology , senescence , human brain , life span , cerebral cortex , psychology , disease , medicine , pathology , microbiology and biotechnology , evolutionary biology , biochemistry , enzyme
Acetylcholinesterase‐rich pyramidal neurons in the human association neocortex and hippocampal formation are virtually absent early in life, become established by adolescence, and appear to increase in density during adulthood and perhaps even senescence. Analogous neurons are not detectable in the adult monkey brain. This Novemberel class of neurons may represent a uniquely human adaptation in primate evolution and may provide a neuroanatomical substrate for the mental development that occurs during the adult stages of life. These phylogenetically and ontogenetically progressive neurons are also Marchkedly vulnerable to degeneration in Alzheimer's disease.