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Chronic remitting‐relapsing experimental allergic encephalomyelitis induced in monkeys with homologous myelin basic protein
Author(s) -
Shaw ChengMei,
Alvord Ellsworth C.,
Hruby Sarka
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240608
Subject(s) - encephalomyelitis , multiple sclerosis , myelin , myelin basic protein , immunology , medicine , homologous chromosome , demyelinating disease , pathology , central nervous system , biology , biochemistry , gene
A chronic remitting‐relapsing form of experimental allergic encephalomyelitis (EAE) has been produced in monkeys sensitized to homologous myelin basic protein in Freund's complete adjuvants by the technique of suboptimal treatment after the onset of disease. Not only does the clinical course resemble that of human multiple sclerosis more closely than does the clinical course of acute EAE, but so also does the histological reaction, with more‐nearly pure demyelination, rather than the hyperacute hemorrhagic‐necrotic lesions that occur so commonly in untreated monkeys with ordinary acute EAE.