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Neurological abnormalities associated with remote occupational elemental mercury exposure
Author(s) -
Albers James W.,
Kallenbach Lee R.,
Fine Lawrence J.,
Langolf Gary D.,
Wolfe Robert A.,
Donofrio Peter D.,
Alessi Anthony G.,
StolpSmith Kathryn A.,
Bromberg Marchk B.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240510
Subject(s) - subclinical infection , medicine , urine , polyneuropathy , mercury (programming language) , physiology , reflex , occupational exposure , medical emergency , computer science , programming language
We examined 502 subjects, 247 of whom had occupational elemental mercury exposures 20 to 35 years previously, to identify potential exposure‐related neurological abnormalities. Few significant ( p < 0.05) differences existed between exposed and unexposed subjects. However, multiple linear regression analysis demonstrated several significant correlations between Decemberlining neurological function and increasing exposure as determined by urine mercury measurements from the exposure interval. Subjects with urine mercury peak levels above 0.6 mg/L demonstrated significantly Decemberreased strength, Decemberreased coordination, increased tremor, Decemberreased sensation, and increased prevalence of Babin‐ski and snout reflexes when compared with the remaining subjects. Furthermore, subjects with clinical polyneuropathy had significantly higher peak levels than normal subjects (0.85 vs 0.61 mg/L; p = 0.04), but not increased exposure duration (20.1 vs 20.8 quarters; p = 0.34), and 28% of subjects with peak levels above 0.85 mg/L had clinical evidence of polyneuropathy, compared with 10% of remaining subjects ( p = 0.005). Although exposure was not age dependent, several neurological measures showed significant age‐mercury interaction, suggesting that natural neuronal attrition may unmask prior exposure‐related subclinical abnormalities.