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Oligoclonai IgG bands in cerebrospinal fluid and serum during asymptomatic human immunodeficiency virus infection
Author(s) -
Grimaldi L. M. E.,
Castagna A.,
Lazzarin A.,
Pristerá R.,
Bianchi G.,
Moroni M.,
Roos R. P.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240219
Subject(s) - cerebrospinal fluid , asymptomatic , pleocytosis , isoelectric focusing , medicine , immunology , virus , human immunodeficiency virus (hiv) , csf pleocytosis , viral disease , asymptomatic carrier , pathology , virology , biology , biochemistry , enzyme
Serum and cerebrospinal fluid (CSF) samples from asymptomatic patients seropositive for human immunodeficiency virus (HIV) showed frequent evidence of intrathecal IgG synthesis and oligoclonai IgG bands, with different isoelectric focusing patterns in serum and CSF; 2 of 7 had a CSF pleocytosis. The results suggest frequent, early, chronic central nervous system infection following HIV infection.