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A crossover trial of bromocriptine in the treatment of vascular dementia
Author(s) -
Nadeau Stephen E.,
Malloy Paul F.,
Andrew Michael E.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240216
Subject(s) - wechsler adult intelligence scale , bromocriptine , crossover study , psychology , dementia , neuropsychology , audiology , neuropsychological test , randomized controlled trial , rating scale , medicine , clinical psychology , psychiatry , cognition , developmental psychology , placebo , alternative medicine , disease , pathology , hormone , prolactin
Seven patients with vascular dementia completed an 8‐month randomized double‐blind crossover trial of bromocriptine in a dosage of up to 30 mg per day. Patients were assessed using a modified UCLA Parkinson Rating Scale of symptoms and signs, and neuropsychological testing including the Wechsler Adult Intelligence Scale‐Revised, Wechsler Memory Scale, modified Thurstone Word Fluency Test, Wisconsin Card Sort, a test of visual vigilance, and a reaction time task. Subjects failed to perform significantly better on any measure while on bromocriptine, and on several measures their performance while on the drug was worse.