Premium
Treatment of patients with neuropathy and anti‐MAG IgM M‐proteins
Author(s) -
NobileOrazio E.,
Baldini L.,
Barbieri S.,
Marchmiroli P.,
Spagnol G.,
Francomano E.,
Scarlato G.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240118
Subject(s) - medicine , gastroenterology
Five patients with neuropathy and IgM M‐proteins that reacted with myelin‐associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a Decemberrease in serum M‐protein and in anti‐MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no Decemberrease of anti‐MAG IgM were observed in the other patients. The close relationship between the Decemberrease of anti‐MAG, M‐proteins and clinical improvement in these patients supports the pathogenetic role of the M‐protein in the neuropathy.