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Neurological basis of respiratory complications in achondroplasia
Author(s) -
Nelson F. William,
Hecht Jacqueline T.,
Horton William A.,
Butler Ian J.,
Goldie William D.,
Miner Michael
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240117
Subject(s) - achondroplasia , medicine , respiratory system , pediatrics
Evaluation of 32 individuals with achondroplasia revealed that 28% had a history of apnea and 22% had respiratory abnormalities on polysomnography. In those patients requiring posterior fossa Decemberompressive surgery, improvement was noted in follow‐up polysomnograms. Multimodality studies suggested that brainstem compression was common in achondroplasia and could account in part for the abnormal respiratory function in this disorder, including obstructive apnea, central apnea, and hypoxemia.