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Expression of nerve growth factor receptor in human peripheral neuropathies
Author(s) -
Sobue Gen,
Yasuda Takeshi,
Mitsuma Terunori,
Ross Alonzo H.,
Pleasure David
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240112
Subject(s) - endoneurium , nerve growth factor , remyelination , receptor , schwann cell , peripheral nervous system , immunostaining , sural nerve , trk receptor , biology , neuroscience , pathology , anatomy , medicine , immunohistochemistry , central nervous system , myelin , sciatic nerve
Nerve growth factor (NGF) receptors in human sural nerve biopsies were detected immunohistochemically using a monoclonal anti‐human NGF receptor antibody. NGF receptors were not visualized within the endoneurium of normal adult nerves but were readily demonstrable within the endoneurium of nerves undergoing active axonal degeneration. Immunostaining of adjacent sections for S‐100β protein, a specific Schwann cell Marchker, suggested that Schwann cells expressed the NGF receptors induced by axonal degeneration. Residual Schwann cells in nerves in which axons were completely depleted also expressed NGF receptors. NGF receptors were not detected in relation to thinly myelinated regenerating axons, nor were they detected in the endoneurium of nerves that had undergone segmental demyelination and remyelination. The increased expression of NGF receptors in human axonal neuropathies may contribute to regeneration by NGF‐responsive neurons in these disorders.