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Validation of clinical diagnostic criteria for Alzheimer's disease
Author(s) -
Morris John C.,
McKeel Daniel W.,
Fulling Keith,
Torack Richard M.,
Berg Leonard
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410240105
Subject(s) - alzheimer's disease , dementia , degenerative disease , disease , medicine , stage (stratigraphy) , senile plaques , inclusion and exclusion criteria , psychology , pathology , alternative medicine , paleontology , biology
Clinical investigations of Alzheimer's disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects with senile dementia of the Alzheimer type (SDAT). In a consecutive series of 26 postmortem examinations from this sample, AD was histologically verified in all subjects and was the priMarchy dementing illness. Seventeen of the 26 SDAT subjects had been diagnosed when only mildly demented. Two control subjects were examined neuropathologically; AD was absent in both. We conclude that research clinical diagnostic criteria for SDAT, even in its mild stage, are valid.