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HTLV‐I‐associated leukemia: A model for chronic retroviral diseases
Author(s) -
Murphy Edward L.,
Blattner William A.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230739
Subject(s) - tropical spastic paraparesis , etiology , leukemia , epidemiology , t cell leukemia , disease , medicine , immunology , lymphoma , malignancy , retrovirus , virology , pathological , virus , human t lymphotropic virus 1 , human t lymphotropic virus , progressive multifocal leukoencephalopathy , myelopathy , pathology , psychiatry , spinal cord
Human T‐lymphotropic virus type I (HTLV‐I) has been associated with adult T‐cell leukemia/lymphoma (ATL), a malignancy of mature CD4‐positive lymphocytes, and with tropical spastic paraparesis (TSP), a demyelinating neurological syndrome. This article describes the clinical and pathological features of ATL and reviews the epidemiology of this disease and of its putative etiological agent, HTLV‐I. From what is known about the molecular biology and epidemiology of HTLV‐I, hypotheses on the etiology of TSP are proposed, and strategies for studying the neurological syndrome are suggested.