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Spastic paraparesis and HTLV‐I infection in peru
Author(s) -
Johnson Richard T.,
Griffin Diane E.,
Arregui Alberto,
Mora Carlos,
Gibbs Clarence J.,
Cuba Juan M.,
Trelles Luis,
Vaisberg Abraham
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230734
Subject(s) - tropical spastic paraparesis , cerebrospinal fluid , myelopathy , monoclonal antibody , peripheral blood mononuclear cell , immunology , antibody , western blot , medicine , human t lymphotropic virus , virology , virus , pathology , biology , gene , spinal cord , biochemistry , psychiatry , in vitro
Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T‐lymphotropic virus type I (HTLV‐I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T‐helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV‐I–associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin‐2 receptors, and decreased natural killer cell activity.