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Preliminary molecular characterization of a human immunodeficiency virus (HIV‐I) associated with neuropathology
Author(s) -
Anand Rita,
Srinivasan A.,
Gardner Murray B.,
Luciw Paul A.,
Dandekar Satya
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230717
Subject(s) - virology , biology , human immunodeficiency virus (hiv) , dementia , transmembrane protein , homology (biology) , sequence analysis , peptide sequence , virus , neuropathology , genetics , amino acid , medicine , gene , receptor , disease , pathology
A human immunodeficiency virus (HIV‐I) was isolated from the brain of a patient with progressive dementia but no obvious immunosuppression. This isolate, designated as HIV‐I BR , was molecularly cloned and sequenced, and its long terminal repeat (LTR) and envelope sequences were compared with those of other HIV isolates not uniquely associated with dementia. The HIV‐I BR LTR showed marked homology with the LTR sequences of the other HIV‐I isolates. The predicted amino acid sequence of the external glycoprotein (gp120) of HIV‐I BR revealed a pattern of conserved and variable regions similar to that of other HIV isolates. The sequence of the transmembrane portion of envelope, gp 41, was highly homologous to the counterpart region of other isolates. Further analysis is required to determine whether specific sequence variation can account for neurological manifestations of HIV‐I BR infection.