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Distinct biological and serological properties of human immunodeficiency viruses from the brain
Author(s) -
ChengMayer Cecilia,
Levy Jay A.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230716
Subject(s) - tropism , virology , serology , biology , neutralization , human immunodeficiency virus (hiv) , human brain , lymph , virus , tissue tropism , immunology , antibody , medicine , pathology , neuroscience
Human immunodeficiency viruses from the brain can be distinguished from peripheral blood isolates by their ability to infect established human cell lines and their sensitivity to serum neutralization. Isolates from the brain and lymph nodes obtained from the same person displayed similar host range tropism and susceptibility to serum neutralization; however, the brain isolate infected macrophages more efficiently. These data suggest that brain isolates may represent a distinct subtype of the human immunodeficiency virus.