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Primary central nervous system lymphomas in patients with AIDS
Author(s) -
Rosenblum Mark L.,
Levy Robert M.,
Bredesen Dale E.,
So Yuen T.,
Wara William,
Ziegler John L.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230707
Subject(s) - medicine , incidence (geometry) , lymphoma , central nervous system , primary central nervous system lymphoma , lesion , biopsy , pathology , radiation therapy , radiology , physics , optics
Primary central nervous system non‐Hodgkin's lymphomas are observed in approximately 1.9% of all patients with acquired immunodeficiency syndrome (AIDS). The yearly incidence of AIDS‐associated tumors has surpassed the yearly incidence from all other causes and could become as frequent as low‐grade astrocytomas by 1991. Patients' signs, symptoms, and radiographic studies are not specific for this lesion; brain biopsy usually is necessary to make a definitive diagnosis. Most tumors are high‐grade lymphomas and are pathologically similar to the primary central nervous system lymphomas observed before the AIDS epidemic. AIDS‐associated tumors respond readily to radiation therapy. However, patient survival remains limited owing to other manifestations of the syndrome.