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Neurofibrillary tangle formation in the nucleus basalis of meynert ipsilateral to a massive cerebral infarct
Author(s) -
Kato Takeo,
Hirano Asao,
Katagiri Tadashi,
Sasaki Hideo,
Yamada Shigeru
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230617
Subject(s) - nucleus basalis , tangle , cerebral cortex , neuroscience , neurofibrillary tangle , cerebral infarction , medicine , cortex (anatomy) , anatomy , pathology , biology , ischemia , alzheimer's disease , central nervous system , cardiology , cholinergic neuron , senile plaques , disease , mathematics , pure mathematics
Two cases of massive cerebral infarct in the territory of the middle cerebral artery on one side of the brain are presented, in which many (Patient 1) or several (Patient 2) neurofibrillary tangle‐bearing neurons were observed in the nucleus basalis of Meynert (nbM), ipsilateral to the infarcts. Tangles were absent or rare in the opposite nbM or in other areas of the brain. Considering the widespread projection of nbM axons to the ipsilateral cerebral cortex, this suggests that formation of neurofibrillary tangles can occur as a retrograde reaction of nbM neurons secondary to massive, old cerebral infarction.