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Stroke associated with obstructive sleep apnea in a child with sickle cell anemia
Author(s) -
Robertson Patricia L.,
Aldrich Michael S.,
Hanash Samir M.,
Goldstein Gary W.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230615
Subject(s) - medicine , hypoxemia , obstructive sleep apnea , sickle cell anemia , anemia , stroke (engine) , apnea , pediatrics , incidence (geometry) , sleep apnea , risk factor , cardiology , disease , mechanical engineering , physics , optics , engineering
We describe a child with sickle cell anemia and multiple ischemic infarctions who was found to have severe obstructive sleep apnea and hypoxemia, secondary to adenotonsillar enlargement. The apnea‐associated hypoxemia likely contributed to the development of the strokes in this child. Moreover, because stroke in patients with sickle cell anemia, and maximal tonsillar enlargement (the most common cause of obstructive apnea in children) both have peak incidence at the same age (6–7 years), obstructive sleep apnea may be an important factor in the development of stroke in other children with sickle cell anemia.