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Complications of long‐term anticoagulation
Author(s) -
Petty G. W.,
Lennihan L.,
Mohr J. P.,
Hauser W. A.,
Weitz J.,
Owen J.,
Towey C.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230607
Subject(s) - term (time) , intensive care medicine , medicine , quantum mechanics , physics
We used life‐table techniques to determine risks of morbidity and mortality associated with long‐term warfarin treatment in an anticoagulation clinic. Cumulative risks for life‐threatening complications and warfarin‐related death among all patients were 1% at 6 months, 5% at 1 year, and 7% at 2 and 3 years. Cox regression analysis using age as a continuous variable failed to show an effect of age on cumulative risks of complication. The occurrence of a minor complication during the course of therapy did not place patients at higher risk for developing a major complication that would prompt discontinuation of therapy or cause death. There was no statistically significant difference between the cumulative risks of patients anticoagulated for cerebrovascular disease and the cumulative risks of patients anticoagulated for other indications.