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Differential cognitive impairment in alzheimer's disease and huntington's disease
Author(s) -
Brandt Jason,
Folstein Susan E.,
Folstein Marshal F.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230605
Subject(s) - huntington's disease , disease , dementia , cognition , alzheimer's disease , degenerative disease , cognitive impairment , psychology , medicine , neuroscience , audiology , pathology
The differentiation between cortical and subcortical dementias requires that the cognitive characteristics of dementias attributable to different causes be discriminable. For large samples of Alzheimer's disease and Huntington's disease patients, distinct cognitive profiles were obtained on the Mini‐Mental State Exam. The profile differences were independent of severity of dementia and were sufficiently robust to classify patients as Alzheimer's disease or Huntington's disease with 84% accuracy. The qualitative differences in cognitive functioning may also be typical of other cortical and subcortical dementias.