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An antineuronal autoantibody in paraneoplastic opsoclonus
Author(s) -
BuddeSteffen Corinna,
Anderson Neil E.,
Rosenblum Mark K.,
Graus Francesc,
Ford David,
Synek Beth J. L.,
Wray Shirley H.,
Posner Jerome B.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230518
Subject(s) - opsoclonus , autoantibody , antibody , medicine , ataxia , immunology , antigen , pathology , neuroblastoma , biology , genetics , psychiatry , cell culture
Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53‐ to 61‐kDa and 79‐ to 84‐kDa antigens in immunoblots of neurons. Anti‐neuronal antibodies were not found in other patients with paraneoplastic opsoclonus.