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Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b
Author(s) -
Nardelli Ettore,
Steck Andreas J.,
Barkas Thomas,
Schluep Myriam,
Jerusalem Felix
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230517
Subject(s) - motor neuron , ganglioside , monoclonal antibody , epitope , neuron , lectin , antibody , lower motor neuron , immunoglobulin m , cerebellum , chemistry , immunology , medicine , immunoglobulin g , biology , neuroscience , biochemistry , spinal cord
We demonstrated that an IgM M‐protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar‐binding lectin suggested that the epitope in the patient's M‐IgM involved the Gal(β1‐3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M‐IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely.