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Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: Human cerebral infarction studied by serial 31 P NMR spectroscopy
Author(s) -
Levine Steven R.,
Welch K. M. A.,
Helpern J. A.,
Chopp Michael,
Bruce Randal,
Selwa James,
Smith Michael B.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230423
Subject(s) - acidosis , medicine , energy metabolism , cerebral infarction , metabolism , nuclear magnetic resonance spectroscopy , in vivo , human brain , metabolic acidosis , ischemic stroke , stroke (engine) , brain infarction , ischemia , anesthesia , chemistry , biology , psychiatry , mechanical engineering , microbiology and biotechnology , engineering , organic chemistry
We report on a patient with a large ischemic hemispherical stroke studied serially by 31 P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high‐energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.