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Cerebrospinal fluid IgG in childhood: The establishment of reference values
Author(s) -
Rust Robert S.,
Dodson W. Edwin,
Trotter John L.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230420
Subject(s) - cerebrospinal fluid , reference values , immunoglobulin g , csf albumin , medicine , normal values , antibody , albumin , immunology , population , pathology , environmental health
A retrospective analysis of quantitative and qualitative immunoglobulin G (IgG) results from 253 children who were either medically and neurologically normal or highly unlikely to have abnormalities of CSF IgG is reported. Normal values in this reference population vary with age for CSF/albumin IgG ratio and CSF/serum IgG index and are significantly different from the adult reference values. The rate of false positivity is lower for quantitative values than for qualitative IgG determinations (oligoclonal bands).