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Changes in benzodiazepine receptors in alzheimer‐type dementia
Author(s) -
Shimohama Shun,
Taniguchi Takashi,
Fujiwara Motohatsu,
Kameyama Masakuni
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230419
Subject(s) - benzodiazepine , flunitrazepam , dementia , hippocampus , receptor , alzheimer's disease , neuroscience , gabaa receptor , medicine , psychology , endocrinology , disease
We studied benzodiazepine receptors in brains obtained at autopsy from 7 normal controls and 7 patients with Alzheimer‐type dementia, using 3 H‐flunitrazepam as a ligand. Compared with controls, 3 H‐flunitrazepam binding sites were significantly reduced in number in frontal and temporal cortex and hippocampus in the Alzheimer‐type dementia brains. These results suggest that there are significant changes in the number of benzodiazepine receptors in selected brain regions of patients with Alzheimer‐type dementia.