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Alz‐50 Antibody recognizes alzheimer‐related neuronal changes
Author(s) -
Hyman B. T.,
Van Hoesen G. W.,
Wolozin B. L.,
Davies P.,
Kromer L. J.,
Damasio A. R.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230410
Subject(s) - pathology , alzheimer's disease , monoclonal antibody , neurofibrillary tangle , biology , antigen , degenerative disease , neuroscience , antibody , senile plaques , disease , medicine , immunology
Alz‐50 is a monoclonal antibody directed against an antigen present in Alzheimer's disease. Unlike conventional pathological stains that reveal only neurons with neurofibrillary tangles (NFTs), Alz‐50 recognizes neurons that contain NFTs and additional neurons that do not. Our investigation of the topographical distribution of both NFT‐containing and non‐NFT‐containing neurons recognized by Alz‐50 reveals that they are both found primarily in certain cytoarchitectural areas and lamina that have been established as consistent sites for NFT pathology. Some of the neurons recognized by Alz‐50 appear histopathologically normal. We suggest that Alz‐50 recognizes an antigen in neurons that both precedes and accompanies NFT formation. Thus, it may mark a point early in cellular pathology before irreversible cytoskeletal and degenerative changes occur.