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Striatal calcium channel antagonist receptors in huntington's disease and parkinson's disease
Author(s) -
Watson Daniel L.,
Carpenter Celia L.,
Marks Shelley S.,
Greenberg David A.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230316
Subject(s) - antagonist , calcium channel , parkinson's disease , neuroscience , disease , huntington's disease , receptor , medicine , calcium , psychology
Abstract The density of calcium channel antagonist receptors labeled by (+)‐[ 3 H]PN 200‐110 was reduced by 75% in striata from patients with Huntington's disease, but unchanged in patients with Parkinson's disease, compared with control subjects. These receptors are therefore likely to be localized to neurons with cell bodies in striatum, rather than nigrostriatal nerve terminals or glia, and their loss may contribute to the pathophysiology of basal ganglia disorders.