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Cerebrospinal fluid antibodies to myelin basic protein in acute idiopathic optic neuritis
Author(s) -
Warren Kenneth G.,
Catz Ingrid,
Bauer Christopher
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230314
Subject(s) - optic neuritis , cerebrospinal fluid , medicine , multiple sclerosis , myelin basic protein , antibody , radioimmunoassay , myelin , pathology , immunology , central nervous system
Free and bound levels of anti‐myelin basic protein (anti‐MBP) antibodies were measured by radioimmunoassay in the cerebrospinal fluid of 20 patients with acute idiopathic optic neuritis, 133 patients with multiple sclerosis (MS) divided into three clinical subgroups, and 76 normal control subjects. Patients with idiopathic optic neuritis had elevated levels of anti‐MBP predominantly in free form, resulting in an elevated (above unity) free/bound anti‐MBP ratio similar to that of MS patients with acute relapses. These data suggest that acute idiopathic optic neuritis, like active MS, is associated with anti‐MBP.