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Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients
Author(s) -
Crisostomo Edgardo A.,
Duncan Pamela W.,
Propst Martha,
Dawson Deborah V.,
Davis James N.
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230117
Subject(s) - amphetamine , stroke (engine) , placebo , rehabilitation , physical medicine and rehabilitation , medicine , motor function , cerebral infarction , physical therapy , motor activity , psychology , anesthesia , psychiatry , mechanical engineering , alternative medicine , ischemia , pathology , engineering , dopamine
We conducted a double‐blind pilot study of 8 patients with established cerebral infarction to evaluate the effect of a single dose of amphetamine on recovery of motor function using the Fugl‐Meyer scale. Four patients received amphetamine; the rest were given placebo. All underwent a session of physical therapy. Patients treated with amphetamine obtained greater increments in motor scores than the controls. Along with animal studies, these findings may allow the development of a pharmacological approach to stroke rehabilitation.