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Prospective nerve conduction studies in cisplatin therapy
Author(s) -
Riggs Jack E.,
Ashraf Mohammed,
Snyder Robert D.,
Gutmann Ludwig
Publication year - 1988
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410230116
Subject(s) - sensory system , cisplatin , medicine , prospective cohort study , sensory nerve , nerve conduction , electrophysiology , anesthesia , surgery , chemotherapy , neuroscience , psychology
We studied nerve conduction prospectively in 38 women receiving cisplatin for gynecological malignancies. Decreased sensory nerve action potential amplitudes and prolonged sensory latencies were the only significant changes identified. This prospective electrophysiological study validates the clinical observation of frequent sensory symptoms and occasional sensory neuropathies associated with cisplatin therapy.