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Visual evoked potentials in patients with neuropathy and macroglobulinemia
Author(s) -
Barbieri S.,
NobileOrazio E.,
Baldini L.,
Fayoumi Z.,
Manfredini E.,
Scarlato G.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410220520
Subject(s) - macroglobulinemia , subclinical infection , central nervous system , cerebrospinal fluid , medicine , myelin , optic neuropathy , polyneuropathy , waldenstrom macroglobulinemia , nervous system , pathology , optic nerve , anatomy , multiple myeloma , lymphoma , psychiatry
Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M‐proteins reacted with myelin‐associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M‐protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M‐protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti‐MAG M‐proteins and may be due to the binding of M‐proteins to central nervous system myelin.