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Soluble IL‐2 receptors in acute and subacute encephalitis
Author(s) -
Boutin B.,
Matsuguchi L.,
Lebon P.,
Ponsot G.,
Artbuis M.,
Nelson D.L.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410220518
Subject(s) - cerebrospinal fluid , encephalitis , subacute sclerosing panencephalitis , receptor , medicine , pathology , immunology , viral encephalitis , interleukin 6 , blood–brain barrier , interleukin , virus , inflammation , central nervous system , cytokine , measles virus , vaccination , measles
Elevated levels of soluble interleukin‐2 receptors were present in the serum from patients with acute primary and postinfectious encephalitis and subacute sclerosing panencephalitis. In addition, soluble interleukin‐2 receptors were detected in the cerebrospinal fluid from patients with acute primary encephalitis. Their presence in the cerebrospinal fluid was not explained by damage to the blood—brain barrier and our data attest to their local origin. This suggests that it may be possible in certain neurological diseases to detect cerebral Tlymphocyte activation through a specific marker in the cerebrospinal fluid.