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Naltrexone decreases self‐injurious behavior
Author(s) -
Herman Barbara H.,
Kathryn Hammock M.,
Bs Ann ArthurSmith,,
Egan James,
Chatoor Irene,
Werner Alisa,
Zelnik Nathaniel
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410220419
Subject(s) - naltrexone , opioid , psychology , opioid peptide , medicine , clinical psychology , endocrinology , receptor
The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self‐injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose‐dependent Decemberreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.