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Search for antibodies to galactocerebroside in the serum and cerebrospinal fluid in human demyelinating disorders
Author(s) -
Rostami A. M.,
Burns J. B.,
Eccleston P. A.,
Manning M. C.,
Lisak R. P.,
Silberberg D. H.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410220316
Subject(s) - galactocerebroside , chronic inflammatory demyelinating polyneuropathy , multiple sclerosis , demyelinating disorder , cerebrospinal fluid , medicine , demyelinating disease , immunology , antibody , antigen , titer , guillain barre syndrome , immune system , pathology , oligodendrocyte , central nervous system , myelin
To determine if galactocerebroside (GalC) is a target antigen in the human demyelinating disorders multiple sclerosis, Guillain‐Barré syndrome, and chronic demyelinating inflammatory polyneuropathy, we examined the serum and cerebrospinal fluid from patients with these disorders and from control subjects using four assay systems. In none of these assays could we detect significant differences in anti‐GalC antibody titer between patients with demyelinating diseases and normal subjects or patients with demyelinating diseases and normal subjects or patients with other neurological disorders. Our data suggest that there is no humoral immune response to GalC in human demyelinating disorders.