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Detection of varicella‐zoster virus nucleic acid in neurons of normal human thoracic ganglia
Author(s) -
Gilden Donald H.,
Rozenman Yaacov,
Murray Ronald,
Devlin Mary,
Vafai Abbas
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410220315
Subject(s) - varicella zoster virus , virus , thoracic ganglia , virology , biology , anatomy , neuroscience , pathology , medicine , nervous system
Tissue sections from four normal human thoracic ganglia were hybridized in situ with a varicella‐zoster virus—RNA probe. Varicella‐zoster virus was detected in two of four ganglia, localized exclusively in neurons. The detection of latent varicella‐zoster virus genetic material in thoracic ganglia provides further evidence of varicella‐zoster virus latency at multiple levels of the human neuraxis and supports the notion that the neuron is the primary site of herpesvirus latency.