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Hippocampal neuron loss in temporal lobe epilepsy: Correlation with early childhood convulsions
Author(s) -
Sagar H. J.,
Oxbury J. M.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410220309
Subject(s) - epilepsy , temporal lobe , hippocampal formation , neuroscience , hippocampal sclerosis , hippocampus , medicine , mesial temporal lobe epilepsy , psychology , audiology
Hippocampal neuron densities in three areas (H 1 zone, end folium, and dentate gyrus) were counted in each of 32 temporal lobectomy excision specimens using the technique of Mouritzen Dam. The association between severe neuronal loss in all three areas and early childhood convulsions that were prolonged and/or lateralized was highly significant. Lesser degrees of neuron loss in H 1 and/or end folium were common and were not associated with early childhood convulsions, but were most often found in older patients with a particularly long history of epilepsy.