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Diencephalic seizures: Responsiveness to bromocriptine and morphine
Author(s) -
Bullard Dennis E.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410210617
Subject(s) - bromocriptine , dopaminergic , opioid , medicine , midbrain , morphine , psychology , neuroscience , anesthesia , dopamine , central nervous system , prolactin , receptor , hormone
Abstract Two patients with posttraumatic diencephalic seizures, characterized by autonomic dysfunction and extensor posturing, had partial responses to bromocriptine and complete responses to morphine. Probable synergism between the two agents was noted. These 2 cases suggest the potential effectiveness of this regimen for the treatment of diencephalic seizures, raise questions regarding the role of the dopaminergic and opioid systems in this disease entity, and support the hypothesis that diencephalic seizures represent a release phenomenon in the brain.