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The magnetic field of complex partial seizures agrees with intracranial localizations
Author(s) -
Sutherling William W.,
Crandall Paul H.,
Engel Jerome,
Darcey Terrance M.,
Cahan Leslie D.,
Barth Daniel S.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410210605
Subject(s) - magnetoencephalography , electroencephalography , scalp , focus (optics) , magnetic resonance imaging , ictal , epilepsy , partial seizures , medicine , neuroscience , audiology , nuclear magnetic resonance , radiology , psychology , physics , anatomy , optics
The magnetoencephalogram (MEG) was recorded during 63 complex partial seizures in 4 patients. The MEG showed large biomagnetic signals occurring at the same time as discharges recorded from scalp electroencephalogram (EEG). These MEG signals had the same morphology and frequency as the discharges from the EEG. The location of the seizure focus was verified by depth electrode recordings in 2 patients and by lesions shown on computed tomographic scan and magnetic resonance imaging in the other 2. In each patient, MEG localization estimates were consistent with the location of the seizure focus shown by other methods. When seizures were recorded repeatedly and mapped with a single‐channel magnetometer placed at different scalp locations in a single patient, the MEG localization agreed with the electrographic seizure focus localized from depth electrodes. In the maps, the MEG resolved an ambiguity in the scalp EEG and therefore increased the confidence of localization. MEG recordings of seizures may help localize epileptic foci noninvasively.