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Phosphofructokinase activity in the brain in Alzheimer's disease
Author(s) -
Sims Neil R.,
Blass John P.,
Murphy Cathleen,
Bowen David M.,
Neary David
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410210517
Subject(s) - phosphofructokinase , neocortex , dementia , alzheimer's disease , disease , degenerative disease , medicine , glycolysis , pathology , neuroscience , psychology , metabolism
The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.