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Linkage of adrenoleukodystrophy to a polymorphic DNA probe
Author(s) -
Aubourg Patrick R.,
Sack George H.,
Meyers Deborah A.,
Lease John J.,
Moser Hugo W.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410210406
Subject(s) - adrenoleukodystrophy , recombination fraction , genetics , linkage (software) , genetic linkage , x chromosome , dna , recombination , biology , microbiology and biotechnology , chromosome , gene , gene mapping , peroxisome
Linkage studies between X‐linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27–28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very‐long‐chain fatty acids.