Premium
The lennox‐gastaut syndrome: Metabolic subtypes determined by 2‐deoxy‐2 [ 18 F]fluoro‐d‐glucose positron emission tomography
Author(s) -
Chugani Harry T.,
Mazziotta John C.,
Engel Jerome,
Phelps Michael E.
Publication year - 1987
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410210104
Subject(s) - positron emission tomography , nuclear medicine , positron , medicine , positron emission , brain function , neuroscience , psychology , physics , quantum mechanics , electron
We employed positron emission tomography (PET) with 2‐deoxy‐2[ 18 F]fluoro‐D‐glucose (FDG) to study local cerebral glucose utilization in 15 children who had Lennox‐Gastaut syndrome. Our results show that LGS can be classified into four predominant subtypes, each with a distinct metabolic pattern: (1) unilaterla focal hypometabolism, (2) unilateral diffuse hypometabolism, (3) bilateral diffuse hypometabolism, and (4) normal. Functional disturbances seen on FDG‐PET did not always correlate with abnormalities revealed by x‐ray computed tomographic scan. This classification of Lennox‐Gastaut syndrome into four major metabolic subtypes not only provides a new perspective toward understanding cerebral function in this complex syndrome, but may also prove useful in the clinical management of these patients.