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Hemispheric brain damage in unilateral status epilepticus
Author(s) -
Soffer Dov,
Melamed Eldad,
Assaf Yaakov,
Cotev Shamay
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410200616
Subject(s) - status epilepticus , coma (optics) , brain damage , epilepsy , medicine , right hemisphere , hemiparesis , cerebral edema , anesthesia , psychology , neuroscience , psychiatry , audiology , lesion , physics , optics
A 20‐year‐old woman with psychomotor seizures developed prolonged unilateral status epilepticus followed by coma, right hemiparesis, fever, liver failure, and eventually death. Neuropathological findings included severe neuronal ischemic cell change and massive brain edema, essentially restricted to the left cerebral hemisphere. Massive destruction of the hemisphere involved in epileptic activity with sparing of the contralateral hemisphere provides supportive evidence that in humans prolonged seizure activity can cause permanent brain damage.