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Japanese encephalitis: Idenufication of inflammatory cells in cerebrospinal fluid
Author(s) -
Johnson Richard T.,
Intralawan Pensri,
Puapanwatton Siriraj
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410200607
Subject(s) - cerebrospinal fluid , encephalitis , cytotoxic t cell , peripheral blood mononuclear cell , medicine , monoclonal antibody , antibody , immunology , microglia , virology , pathology , inflammation , biology , virus , in vitro , biochemistry
Fifteen patients with acute encephalitis were studied during the epidemic season of Japanese encephalitis (JE) in Northern Thailand; 13 of 15 proved to have the encephalitis. In serial cerebrospinal fluids and blood samples, mononuclear cells were identified using monoclonal antibodies. In cerebrospinal fluid from the patients with Japanese encephalitis, T cells predominated with a 4.2:1 ratio of T helper/inducer cells to T suppressor/cytotoxic cells; B cells and macrophages were often present but in small numbers compared to their presence in blood. Distribution of cell types did not vary between the first and fifth day of hospitalization, were similar in fatal and nonfatal cases, and were unaffected by administration of steroids.