Premium
Primary central nervous system lymphoma in acquired immune deficiency syndrome: A clinical and pathological study
Author(s) -
So Yuen T.,
Beckstead Jay H.,
Davis Richard L.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410200503
Subject(s) - autopsy , medicine , pathological , pathology , lymphoma , primary central nervous system lymphoma , cerebrospinal fluid , central nervous system , biopsy , immune system , immunology
Twenty cases of primary lymphoma of the centratl nervous system associated with acquired immune deficiency syndrome were seen over a period of four years and were studied clinically and pathologically. Biopsy established the diagnosis in 11 cases, and autopsy confirmed it in 9. Multicentricity was demonstrated in all cases for which there was adequate autopsy material. Both large‐cell immunoblastic and small noncleaved lymphomas were seen, and marker studies in 5 patients established that the lymphomas were of B‐cell origin. Neurological symptoms and signs, cerebrospinal fluid characteristics, and radiographic appearance were reviewed. The clinical and radiographic picture is nonspecific and histological confirmation is essential for diagnosis. Although the tumor appears to be radiosensitive, prognosis is extremely poor, with an average survival of less than two months.