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Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sjögren's syndrome
Author(s) -
Malinow K.,
Yannakakis G. D.,
Glusman S. M.,
Edlow D. W.,
Griffin J.,
Pestronk A.,
Powell D. L.,
RamseyGoldman R.,
Eidelman B. H.,
Medsger T. A.,
Alexander E. L.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410200416
Subject(s) - dorsal root ganglion , medicine , trigeminal ganglion , sensory system , pathology , lymphocytic infiltration , pathogenesis , dorsum , ganglion , biopsy , trigeminal nerve , sensory neuron , skin biopsy , anatomy , neuroscience , biology
Abstract Sensory neuropathies, particularly trigeminal neuropathy, have been recognized as neurological complications of Sjögren's syndrome, but the pathogenesis has not been established. We describe a woman with primary Sjögren's syndrome who developed a progressive debilitating subacute sensory neuronopathy. Results of electrophysiological studies were consistent with involvement of the trigeminal and dorsal root ganglia. A thoracic dorsal root ganglion biopsy showed lymphocytic infiltration and degeneration of ganglion cells. We believe that this is the first description of biopsy‐documented dorsal root ganglionitis in a subacute sensory neuronopathy associated with Sjögren's syndrome and that the finding suggests an immunopathogenic basis.