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Localization and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene–related peptide in human temporal arteries
Author(s) -
Jansen Inger,
Uddman Rolf,
Hocherman Max,
Ekman Rolf,
Jensen Kai,
Olesen Jes,
Srienholm Pia,
Edvinsson Lars
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410200409
Subject(s) - vasoactive intestinal peptide , neuropeptide , neuropeptide y receptor , substance p , calcitonin gene related peptide , endocrinology , medicine , calcitonin , vasoactive , peptide , peptide hormone , chemistry , receptor , hormone , biochemistry
Nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), and calcitonin gene–related peptide (CGRP) were seen in the adventitia or at the adventitia–media border of the human temporal artery. Pharmacological experiments on isolated temporal artery segments revealed that NPY potentiated the vasoconstrictor responses to noradrenaline, but had no vasoconstrictor ability or only a small vasoconstrictor ability per se. VIP, peptide histidine methionine 27 (PHM‐27), SP, neurokinin A (NKA), and CGRP potently relaxed vessels precontracted by prostaglandin F 2α , the relative potency being CGRP > SP > NKA VIP PHM‐27. The amount of relaxation varied between 67 and 91% of the prostaglandin F 2α –induced contraction. The peptide effects were not antagonized by classic adrenergic or cholinergic blockers, suggesting interactions via separate receptor sites.