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Widespread reduction of somatostatin‐like immunoreactivity in the cerebral cortex in Alzheimer's disease
Author(s) -
Beal M. Flint,
Mazurek Michael F.,
Svendsen Clive N.,
Bird Edward D.,
Martin Joseph B.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410200408
Subject(s) - somatostatin , cerebral cortex , alzheimer's disease , temporal lobe , temporal cortex , degenerative disease , cortex (anatomy) , frontal lobe , neuroscience , central nervous system disease , pathology , disease , psychology , medicine , epilepsy
Although several studies have documented reduced concentrations of somatostatin‐like immunoreactivity (SLI) in the cerebral cortex in Alzheimer's disease, there is controversy concerning the extent and importance of these changes. We measured SLI in brains obtained post mortem from 12 patients with pathologically confirmed Alzheimer's disease and from 13 neurologically normal controls. All major cortical and subcortical regions were examined. Widespread reductions of SLI in Alzheimer's disease cerebral cortex were found, with the most profound changes seen in temporal lobe; but there also were major reductions in both the frontal and occipital cortex. There were no significant reductions in subcortical regions. Characterization of SLI by high‐pressure liquid chromatography showed no significant difference in profiles between Alzheimer's disease and control frontal cortex. These results suggest that the reduction in somatostatin immunoreactivity in Alzheimer's disease may be caused by degeneration of intrinsic somatostatin cortical neurons.